Overview of Research
Professor John F. Cryan, Chair at UCC’s Department of Anatomy & Neuroscience, is leading groundbreaking research on the connection between the gut and the brain. This €4.8 million grant will support investigations into how the gut microbiome influences immune and neuropsychiatric conditions, with a focus on autism and other neurodevelopmental disorders.
Innovative Research on Gut-Brain Axis
Early animal studies, particularly in mice, have laid the foundation for this research, which aims to develop novel therapeutic approaches targeting gut-brain communication.
In 2014, Professor Cryan and Dr. Mark Lyte of Texas Tech University co-authored the landmark book Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. Dr. Lyte’s 25 years of research have demonstrated that gut microbes communicate with the nervous system via neurochemicals used in brain signaling.
Current Research Focus Areas
Professor Cryan’s research explores:
- Stress-Related Neuropsychiatric Disorders: Investigating the biological underpinnings of conditions such as depression, anxiety, and drug dependence.
- Gut-Brain-Microbiome Interaction: Understanding its role in stress, immune-related disorders (e.g., IBS, obesity), and neurodevelopmental disorders like autism.
- Innovative Drug Delivery: Developing new methods for siRNA and drug delivery to the brain.
A Collaborative and Diverse Research Team
Prof. Cryan’s research group consists of:
- 12 Postdoctoral Fellows
- 14 PhD Students
- 2 MD Students
- 2 MSc Students
- 3 Research Scientists
- Numerous visiting students from Ireland, Spain, The Netherlands, the USA, and Canada
The group is funded by major organizations such as Science Foundation Ireland, the Health Research Board, Enterprise Ireland, the Irish Research Council, and the EU Framework 7 Programme.
A New Era in Gut-Brain Research
Professor Cryan and Dr. Lyte’s work is ushering in a transformative era of discovery in gut-brain connection studies, with the potential to revolutionize treatments for neuropsychiatric and immune-related disorders. Their research highlights the vital role of the microbiome in brain health, paving the way for innovative therapies and interventions.